Zonulin(連蛋白)是一種參與上皮和內皮屏障功能調節的蛋白質,對腸粘膜細胞緊密連接的調節對于維持屏障內環境的平衡至關重要,zonulin是目前唯一已知的細胞間緊密連接的生理調節劑,參與大分子的運輸和耐受/免疫反應平衡。當連蛋白與腸的上皮細胞結合時,會誘導信號級聯。這種級聯分解了腸壁的細胞旁緊密連接。腸壁的緊密連接是允許分子從腸腔轉移到血流的兩種方式之一,反之亦然。當腸道中的連蛋白水平增加并失去平衡時,這些連接點會打開得更寬,并保持更長時間。這些加寬的入口點允許較大的大分子進入血液或腸腔。通過這些缺口的分子可以增加身體的自然免疫反應,引起炎癥和一些自身免疫性疾病。
與 Zonulin 水平升高相關的疾?。?/p>
1型糖尿病
類風濕關節炎
乳糜瀉
肝病
作為專業的生命科學醫藥原料供應商,艾美捷科技為您推薦Immundiagnostik榮譽產品,連蛋白Zonulin檢測試劑盒:適用于血清(Serum)和糞便(stool)樣本!
產品名稱 | 貨號 | 樣本類型 | 說明書下載 | 備注 |
IDK? Zonulin (Stool) ELISA | K 5600 | Stool / 糞便 | 點擊下載 | 僅科研用途(歐盟CE) |
IDK? Zonulin (Stool) ELISA | KR5600 | Stool / 糞便 | 點擊下載 | 僅科研用途 |
IDK? Zonulin (Serum) ELISA | K 5601 | Serum / 血清 | 點擊下載 | 僅科研用途 |
* Immundiagnostik榮譽出品..僅供科研使用,不得用于醫療.
Zonulin產品已發表文章:
Parker, Jim, Claire O’brien, and Jason Hawrelak. "A narrative review of the role of gastrointestinal dysbiosis in the pathogenesis of polycystic ovary syndrome." Obstetrics & Gynecology Science 65.1 (2022): 14-28.
Kleppe, Malin M., et al. "Intestinal barrier integrity in anorexia nervosa (a pilot study)." International Journal of Eating Disorders (2022).
Meira de-Faria, Felipe, et al. "Colonic paracellular permeability and circulating zonulin-related proteins." Scandinavian Journal of Gastroenterology 56.4 (2021): 424-431.
Tatucu-Babet, Oana A., et al. "Serum zonulin measured by enzyme-linked immunosorbent assay may not be a reliable marker of small intestinal permeability in healthy adults." Nutrition Research 78 (2020): 82-92.
Xu, Yiyi, et al. "Inflammatory bowel disease and biomarkers of gut inflammation and permeability in a community with high exposure to perfluoroalkyl substances through drinking water." Environmental Research 181 (2020): 108923.
Scherf, Katharina Anne, et al. "Cofactors of wheat-dependent exercise-induced anaphylaxis do not increase highly individual gliadin absorption in healthy volunteers." Clinical and translational allergy 9.1 (2019): 1-12.
Kanerva, Sonja. "Assessment of immunological methods for quantification of human zonulin and the effects of intestinal bacteria on zonulin secretion in vitro." (2019).
Ajamian, Mary, et al. "Serum zonulin as a marker of intestinal mucosal barrier function: May not be what it seems." PloS one 14.1 (2019): e0210728.
Shariatpanahi, Zahra Vahdat, et al. "Effects of early enteral glutamine supplementation on intestinal permeability in critically ill patients." Indian Journal of Critical Care Medicine: Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine 23.8 (2019): 356.
Scheffler, Lucas, et al. "Widely used commercial ELISA does not detect precursor of haptoglobin2, but recognizes properdin as a potential second member of the zonulin family." Frontiers in endocrinology 9 (2018): 22.
Mokkala, K., et al. "Evaluation of serum zonulin for use as an early predictor for gestational diabetes." Nutrition & diabetes 7.3 (2017): e253-e253.
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